PEBC MCQ Special Populations & Other Therapeutics question: before and during therapy

PEBC MCQSpecial Populations & Other Therapeutics

A dermatologist prescribes isotretinoin for KF, a 20 year old woman with severe nodular acne that did not respond to oral antibiotics. KF is sexually active. Which requirement is most important before and during therapy?

a. Negative pregnancy tests and two forms of contraception
b. Avoiding all dairy products during treatment
c. Daily vitamin A supplements to replace losses
d. Monthly eye examinations to screen for drug-induced cataracts

Show the answer and explanation

Answer: a. Negative pregnancy tests and two forms of contraception

Isotretinoin is highly teratogenic. The Canadian monograph and pregnancy prevention program require negative pregnancy tests before, during and after treatment and the use of two effective forms of contraception from 1 month before, during, and for 1 month after therapy in people who can become pregnant. Vitamin A supplements add toxicity, and dairy and routine eye exams are not the key requirements. Source: Isotretinoin (Epuris/Clarus) product monograph, Serious warnings and pregnancy prevention program (DPD, checked 2026).

Common mistake

Underestimating isotretinoin's teratogenic risk management.

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Original practice material written to the public PEBC blueprint; not a past or real exam question. Not affiliated with or endorsed by The Pharmacy Examining Board of Canada (PEBC). Educational practice material for exam preparation only. Not medical advice and not a substitute for current product monographs, clinical guidelines or professional judgement. Questions have not yet been reviewed by a licensed pharmacist.